Paul,
Apologies if you’ve already been through this thought process, but be aware that sticking 200kg in the front of a Spitfire changes it nature completely. It’s not just a Spit with more grunt. There’s a considerable loss of nimbleness. Also, more grunt…. Actually a well sorted 1500 will be quicker than a standard GT6 in the twisty bits and possibly in a straight line too. And a 4 pot costs about 40% less to do serious engine work to. And this is coming from the owner of two 6 pot cars! Ok, so the 6 sounds so much better……
If you already past the above. Then the chassis is basically the same. I built my GT6 on a 1500 chassis. Up front you would need to add the rad mounts if running a GT6 radiator, though maybe not as it’s possible even preferable to use a light, cheap Golf mk2 GTI, which involves making your own mounting arrangements. I did add the mounts, I also used the Golf radiator - can’t remember if the two got joined.
Gearbox… meh, ideally a beefed-up three rail GT6/Dolly 1850 hybrid with J-type. Otherwise a Ford T9 conversion but make sure you get a 2.8 V8 T9 box.
Spit 1500 3.63 diff is fine (best simple option anyway). Rear brakes also.
Still think a well tweaked 1500 on EFI has many benefits..,,